Pentravan® has demonstrated to be an effective vehicle for the administration of hormones via the vaginal mucosa[1-6]. This route of administration provides high tissue levels of hormones and other active pharmaceutical ingredients (APIs) in the pelvic region, with relatively low systemic blood levels that can cause androgenic side effects. This makes vaginal administration with Pentravan® a very promising route for treating women with a variety of hormonal related conditions.
In a recently published open clinical trial 47 patients with endometriosis and pain were treated with vaginal application of gestrinone in Pentravan®, together with oral pinus pinaster extract and resveratrol (natural polyphenols with antioxidant and anti inflammatory properties) daily.
These patients scored their pain at 9 out of 10 before treatment. After three months all patients were pain-free, bleeding stopped and uterine and ovarian cyst volume decreased. There were no statistically significant changes in total cholesterol, baseline FSH or LH. HDL-cholesterol, triglycerides, total testosterone and estradiol levels decreased significantly. These preliminary results show that vaginal application gestrinone in Pentravan® with oral resveratrol and pinus pinaster extract is an effective treatment for endometriosis-related pain .
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 H. Maia Jr.1,2, C. Haddad2, R. Maia2 et al. Pulsatile administration of testosterone by the vaginal route using Pentravan®. Monduzzi Editoriale. 2013;181-184.
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 Dominique De Ziegler, Carlo Bulletti, Béatrice de Monstier et al. The First Uterine Pass Effect. The Uterus: Endometrium and Myometrium, Annals of the New York Academy of Sciences.1997; 828: 291-299.
 Maia H Jr, Haddad C, dos Santos Junior WSD, et al. Clinical Experience with Vaginal Gestrinone in Pentravan® in the Treatment of Endometriosis Pain. Austin J Reprod Med Infertil. 2015; 2(4): 1021.